7S1M
Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 1)
Summary for 7S1M
Entry DOI | 10.2210/pdb7s1m/pdb |
EMDB information | 24805 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | glucagon, glp-1, exendin, g protein, gdp, gtp, complex, agonist, d-alanine, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 164328.10 |
Authors | Cary, B.P.,Gellman, S.H. (deposition date: 2021-09-02, release date: 2022-01-05, Last modification date: 2022-03-16) |
Primary citation | Cary, B.P.,Deganutti, G.,Zhao, P.,Truong, T.T.,Piper, S.J.,Liu, X.,Belousoff, M.J.,Danev, R.,Sexton, P.M.,Wootten, D.,Gellman, S.H. Structural and functional diversity among agonist-bound states of the GLP-1 receptor. Nat.Chem.Biol., 18:256-263, 2022 Cited by PubMed: 34937906DOI: 10.1038/s41589-021-00945-w PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.41 Å) |
Structure validation
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