7S17

Crystal structure of human G3BP1-NTF2 with three mutations- F15W, F33W, and F124W

Summary for 7S17

Entry DOI	10.2210/pdb7s17/pdb
Related	4FCJ
Descriptor	Ras GTPase-activating protein-binding protein 1 (2 entities in total)
Functional Keywords	ntf2-like domain, binding mutant, rna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	32092.42
Authors	Sheehan, C.T.,Madden, D.R. (deposition date: 2021-09-01, release date: 2022-10-12, Last modification date: 2023-10-25)
Primary citation	Sheehan, C.T.,Hampton, T.H.,Madden, D.R. Tryptophan mutations in G3BP1 tune the stability of a cellular signaling hub by weakening transient interactions with Caprin1 and USP10. J.Biol.Chem., 298:102552-102552, 2022 Cited by PubMed: 36183834 DOI: 10.1016/j.jbc.2022.102552 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.36 Å)

Structure validation