7RYX
S. CEREVISIAE CYP51 COMPLEXED WITH VT-1129
Summary for 7RYX
Entry DOI | 10.2210/pdb7ryx/pdb |
Related | 5UL0 |
Descriptor | Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, (2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-{5-[4-(trifluoromethoxy)phenyl]pyridin-2-yl}propan-2-ol, ... (4 entities in total) |
Functional Keywords | vt-1129, cyp51, oxidoreductase-oxidoreductase inhibitor complex, sterol biosynthesis, oxidoreductase, oxidoreductase/oxidoreductase inhibitor |
Biological source | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) |
Total number of polymer chains | 1 |
Total formula weight | 62600.62 |
Authors | Ruma, Y.N.,Sagatova, A.,Keniya, M.V.,Tyndall, J.D.,Monk, B.C. (deposition date: 2021-08-26, release date: 2021-09-08, Last modification date: 2023-10-18) |
Primary citation | Ruma, Y.N.,Keniya, M.V.,Tyndall, J.D.A.,Monk, B.C. Characterisation of Candida parapsilosis CYP51 as a Drug Target Using Saccharomyces cerevisiae as Host. J Fungi, 8:-, 2022 Cited by PubMed: 35050009DOI: 10.3390/jof8010069 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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