7RYA

S. CEREVISIAE CYP51 I471T MUTANT COMPLEXED WITH ITRACONAZOLE

7RYA の概要

• エントリーDOI: 10.2210/pdb7rya/pdb
• 関連するPDBエントリー: 4ZDY 4ZE2 5EQB 5ESG 5ESH 5ESK 5ESL
• 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, ... (4 entities in total)
• 機能のキーワード: cyp51, oxidoreductase-oxidoreductase inhibitor complex, sterol biosynthesis, oxidoreductase, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63195.28

構造登録者

Graham, D.O.,Wilson, R.K.,Ruma, Y.N.,Keniya, M.V.,Tyndall, J.D.,Monk, B.C. (登録日: 2021-08-24, 公開日: 2021-09-01, 最終更新日: 2023-10-18)

• 主引用文献: Graham, D.O.,Wilson, R.K.,Ruma, Y.N.,Keniya, M.V.,Tyndall, J.D.A.,Monk, B.C.; Structural Insights into the Azole Resistance of the Candida albicans Darlington Strain Using Saccharomyces cerevisiae Lanosterol 14 alpha-Demethylase as a Surrogate.; J Fungi (Basel), 7:-, 2021; PubMed: 34829185; DOI: 10.3390/jof7110897

実験手法

X-RAY DIFFRACTION (2.1 Å)