5EQB

Crystal structure of lanosterol 14-alpha demethylase with intact transmembrane domain bound to itraconazole

Replaces:  4K0F

Summary for 5EQB

• Entry DOI: 10.2210/pdb5eqb/pdb
• Descriptor: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, ... (4 entities in total)
• Functional Keywords: sterol antifungal membrane cytochrome, structural genomics, psi-2, protein structure initiative, center for structures of membrane proteins, csmp, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
• Cellular location: Membrane; Single-pass membrane protein: P10614
• Total number of polymer chains: 1
• Total formula weight: 63207.33

Authors

Monk, B.C.,Tomasiak, T.M.,Keniya, M.V.,Huschmann, F.U.,Tyndall, J.D.A.,O'Connell III, J.D.,Cannon, R.D.,Finer-Morre, J.,Stroud, R.M.,Center for Structures of Membrane Proteins (CSMP) (deposition date: 2015-11-12, release date: 2016-01-13, Last modification date: 2024-03-06)

• Primary citation: Monk, B.C.,Tomasiak, T.M.,Keniya, M.V.,Huschmann, F.U.,Tyndall, J.D.,O'Connell, J.D.,Cannon, R.D.,McDonald, J.G.,Rodriguez, A.,Finer-Moore, J.S.,Stroud, R.M.; Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer.; Proc.Natl.Acad.Sci.USA, 111:3865-3870, 2014; PubMed: 24613931; DOI: 10.1073/pnas.1324245111

Experimental method

X-RAY DIFFRACTION (2.19 Å)