7RWI
Mycobacterium tuberculosis RNA polymerase sigma L holoenzyme open promoter complex containing TNP-2198
Summary for 7RWI
Entry DOI | 10.2210/pdb7rwi/pdb |
Descriptor | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (8 entities in total) |
Functional Keywords | mycobacterium tuberculosis, rna polymerase, transcription inhibitor, tnp-2198, open promoter complex, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Mycobacterium tuberculosis More |
Total number of polymer chains | 8 |
Total formula weight | 400329.70 |
Authors | Molodtsov, V.,Ebright, R.H. (deposition date: 2021-08-19, release date: 2022-03-02, Last modification date: 2023-10-18) |
Primary citation | Ma, Z.,He, S.,Yuan, Y.,Zhuang, Z.,Liu, Y.,Wang, H.,Chen, J.,Xu, X.,Ding, C.,Molodtsov, V.,Lin, W.,Robertson, G.T.,Weiss, W.J.,Pulse, M.,Nguyen, P.,Duncan, L.,Doyle, T.,Ebright, R.H.,Lynch, A.S. Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. J.Med.Chem., 65:4481-4495, 2022 Cited by PubMed: 35175750DOI: 10.1021/acs.jmedchem.1c02045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.7 Å) |
Structure validation
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