7RW7

Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor Compound 9

7RW7 の概要

• エントリーDOI: 10.2210/pdb7rw7/pdb
• 関連するPDBエントリー: 7KCC 7RW5
• 分子名称: S-adenosylmethionine synthase isoform type-2, S-ADENOSYLMETHIONINE, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: methionine adenosyltransferase, sam, allosteric inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45090.98

構造登録者

Jin, L.,Padyana, A.K. (登録日: 2021-08-19, 公開日: 2022-03-23, 最終更新日: 2023-10-18)

• 主引用文献: Li, M.,Konteatis, Z.,Nagaraja, N.,Chen, Y.,Zhou, S.,Ma, G.,Gross, S.,Marjon, K.,Hyer, M.L.,Mandley, E.,Lein, M.,Padyana, A.K.,Jin, L.,Tong, S.,Peters, R.,Murtie, J.,Travins, J.,Medeiros, M.,Liu, P.,Frank, V.,Judd, E.T.,Biller, S.A.,Marks, K.M.,Sui, Z.,Reznik, S.K.; Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads.; J.Med.Chem., 65:4600-4615, 2022; PubMed: 35293760; DOI: 10.1021/acs.jmedchem.1c01595

実験手法

X-RAY DIFFRACTION (1.19 Å)