7RTP
Structure of full-length human lambda-6A light chain JTO in complex with urea stabilizer 20 [1-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-3-(pyridin-3-ylmethyl)urea]
Summary for 7RTP
Entry DOI | 10.2210/pdb7rtp/pdb |
Descriptor | JTO light chain, PHOSPHATE ION, N-{2-[7-(diethylamino)-4-methyl-2-oxo-2H-1-benzopyran-3-yl]ethyl}-N'-[(pyridin-3-yl)methyl]urea, ... (4 entities in total) |
Functional Keywords | amyloidosis, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 47021.52 |
Authors | Yan, N.L.,Wilson, I.A.,Kelly, J.W. (deposition date: 2021-08-13, release date: 2022-02-16, Last modification date: 2023-10-18) |
Primary citation | Yan, N.L.,Nair, R.,Chu, A.,Wilson, I.A.,Johnson, K.A.,Morgan, G.J.,Kelly, J.W. Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site. Bioorg.Med.Chem.Lett., 60:128571-128571, 2022 Cited by PubMed: 35065233DOI: 10.1016/j.bmcl.2022.128571 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.09 Å) |
Structure validation
Download full validation report