7RTC
Crystal structure of the ARM domain from Drosophila SARM1 in complex with NaMN
Summary for 7RTC
Entry DOI | 10.2210/pdb7rtc/pdb |
Descriptor | NAD(+) hydrolase sarm1, NICOTINATE MONONUCLEOTIDE (2 entities in total) |
Functional Keywords | axon degeneration, arm domain, inhibitor, hydrolase |
Biological source | Drosophila melanogaster (Fruit fly) |
Total number of polymer chains | 3 |
Total formula weight | 121418.55 |
Authors | |
Primary citation | Sasaki, Y.,Zhu, J.,Shi, Y.,Gu, W.,Kobe, B.,Ve, T.,DiAntonio, A.,Milbrandt, J. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Exp Neurol, 345:113842-113842, 2021 Cited by PubMed: 34403688DOI: 10.1016/j.expneurol.2021.113842 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.31 Å) |
Structure validation
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