7RSM

Crystal structure of pyrrolysyl-tRNA synthetase (N346D/C348S/Y384F) in complex with o-Chlorophenylalanine and AMP-PNP

Summary for 7RSM

Entry DOI	10.2210/pdb7rsm/pdb
Descriptor	Pyrrolysine--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 2-chloro-L-phenylalanine, ... (4 entities in total)
Functional Keywords	trna synthetase, pylrs, o-chlorophenylalanine, rna binding protein
Biological source	Methanosarcina mazei (Methanosarcina frisia)
Total number of polymer chains	4
Total formula weight	126236.76
Authors	Yang, K.,Liu, W. (deposition date: 2021-08-11, release date: 2022-07-20, Last modification date: 2023-11-15)
Primary citation	Vatansever, E.C.,Yang, K.S.,Geng, Z.Z.,Qiao, Y.,Li, P.,Xu, S.,Liu, W.R. A Designed, Highly Efficient Pyrrolysyl-tRNA Synthetase Mutant Binds o-Chlorophenylalanine Using Two Halogen Bonds. J.Mol.Biol., 434:167534-167534, 2022 Cited by PubMed: 35278475 DOI: 10.1016/j.jmb.2022.167534 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation