7RSM

Crystal structure of pyrrolysyl-tRNA synthetase (N346D/C348S/Y384F) in complex with o-Chlorophenylalanine and AMP-PNP

7RSM の概要

• エントリーDOI: 10.2210/pdb7rsm/pdb
• 分子名称: Pyrrolysine--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 2-chloro-L-phenylalanine, ... (4 entities in total)
• 機能のキーワード: trna synthetase, pylrs, o-chlorophenylalanine, rna binding protein
• 由来する生物種: Methanosarcina mazei (Methanosarcina frisia)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 126236.76

構造登録者

Yang, K.,Liu, W. (登録日: 2021-08-11, 公開日: 2022-07-20, 最終更新日: 2023-11-15)

• 主引用文献: Vatansever, E.C.,Yang, K.S.,Geng, Z.Z.,Qiao, Y.,Li, P.,Xu, S.,Liu, W.R.; A Designed, Highly Efficient Pyrrolysyl-tRNA Synthetase Mutant Binds o-Chlorophenylalanine Using Two Halogen Bonds.; J.Mol.Biol., 434:167534-167534, 2022; PubMed: 35278475; DOI: 10.1016/j.jmb.2022.167534

実験手法

X-RAY DIFFRACTION (2.15 Å)