7RPV

Crystal structure of affinity-enhancing and catalytically inactive ACE2 in complex with SARS-CoV-2 RBD

7RPV の概要

• エントリーDOI: 10.2210/pdb7rpv/pdb
• 分子名称: Processed angiotensin-converting enzyme 2, Spike protein S1, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: sars-cov-2, receptor binding domain, engineered human ace2, enhanced affinity, catalytic-null, zinc binding site, hydrolase-viral protein complex, hydrolase/viral protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 380059.28

構造登録者

Chen, Y.,Tolbert, D.W.,Pazgier, M. (登録日: 2021-08-04, 公開日: 2021-12-15, 最終更新日: 2023-10-18)

• 主引用文献: Chen, Y.,Sun, L.,Ullah, I.,Beaudoin-Bussieres, G.,Anand, S.P.,Hederman, A.P.,Tolbert, W.D.,Sherburn, R.,Nguyen, D.N.,Marchitto, L.,Ding, S.,Wu, D.,Luo, Y.,Gottumukkala, S.,Moran, S.,Kumar, P.,Piszczek, G.,Mothes, W.,Ackerman, M.E.,Finzi, A.,Uchil, P.D.,Gonzalez, F.J.,Pazgier, M.; Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.; Biorxiv, 2021; PubMed: 34845451; DOI: 10.1101/2021.11.24.469776

実験手法

X-RAY DIFFRACTION (3.54 Å)