7RPD

X-ray crystal structure of OXA-24/40 V130D in complex with ertapenem

Summary for 7RPD

Entry DOI	10.2210/pdb7rpd/pdb
Descriptor	Beta-lactamase, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, BICARBONATE ION, ... (5 entities in total)
Functional Keywords	acyl-enzyme complex, carbapenemase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Acinetobacter baumannii
Total number of polymer chains	1
Total formula weight	28386.44
Authors	Powers, R.A.,Mitchell, J.M.,June, C.M. (deposition date: 2021-08-03, release date: 2022-07-06, Last modification date: 2023-10-18)
Primary citation	Mitchell, J.M.,June, C.M.,Baggett, V.L.,Lowe, B.C.,Ruble, J.F.,Bonomo, R.A.,Leonard, D.A.,Powers, R.A. Conformational flexibility in carbapenem hydrolysis drives substrate specificity of the class D carbapenemase OXA-24/40. J.Biol.Chem., 298:102127-102127, 2022 Cited by PubMed: 35709986 DOI: 10.1016/j.jbc.2022.102127 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation