7RN7
Crystal structure of caspase-3 with inhibitor Ac-VD(Aly)VD-CHO
Summary for 7RN7
Entry DOI | 10.2210/pdb7rn7/pdb |
Descriptor | Caspase-3 subunit p17, Caspase-3 subunit p12, Ac-VD(Aly)VD-CHO, ... (4 entities in total) |
Functional Keywords | hydrolase/hydrolase inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 55935.88 |
Authors | McCue, W.,Finzel, B.C. (deposition date: 2021-07-29, release date: 2022-01-05, Last modification date: 2023-11-15) |
Primary citation | Bresinsky, M.,Strasser, J.M.,Vallaster, B.,Liu, P.,McCue, W.M.,Fuller, J.,Hubmann, A.,Singh, G.,Nelson, K.M.,Cuellar, M.E.,Wilmot, C.M.,Finzel, B.C.,Ashe, K.H.,Walters, M.A.,Pockes, S. Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314. Acs Pharmacol Transl Sci, 5:20-40, 2022 Cited by PubMed: 35059567DOI: 10.1021/acsptsci.1c00251 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)