7RN6

High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to type-II inhibitor BBT594

Summary for 7RN6

• Entry DOI: 10.2210/pdb7rn6/pdb
• Descriptor: Tyrosine-protein kinase JAK2, 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1H-indole-1-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: janus kinase, phosphatase, myeloproliferative diseases, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 35633.59

Authors

Karim, M.R.,Schonbrunn, E. (deposition date: 2021-07-29, release date: 2021-11-03, Last modification date: 2023-11-15)

• Primary citation: Karim, M.R.,Schonbrunn, E.; High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to type-II inhibitor BBT594; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)