7RN6

High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to type-II inhibitor BBT594

7RN6 の概要

• エントリーDOI: 10.2210/pdb7rn6/pdb
• 分子名称: Tyrosine-protein kinase JAK2, 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1H-indole-1-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: janus kinase, phosphatase, myeloproliferative diseases, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35633.59

構造登録者

Karim, M.R.,Schonbrunn, E. (登録日: 2021-07-29, 公開日: 2021-11-03, 最終更新日: 2023-11-15)

• 主引用文献: Karim, M.R.,Schonbrunn, E.; High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to type-II inhibitor BBT594; To Be Published,

実験手法

X-RAY DIFFRACTION (1.5 Å)