7RMH
Substance P bound to active human neurokinin 1 receptor in complex with miniGs399
Summary for 7RMH
Entry DOI | 10.2210/pdb7rmh/pdb |
EMDB information | 24570 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | substance p, g protein, gpcr, neurokinin, tachykinin, signaling protein, signaling protein-membrane protein complex, signaling protein/membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 141547.57 |
Authors | Harris, J.A.,Faust, B.,Gondin, A.B.,Daemgen, M.A.,Suomivuori, C.M.,Veldhuis, N.A.,Cheng, Y.,Dror, R.O.,Thal, D.,Manglik, A. (deposition date: 2021-07-27, release date: 2021-11-03, Last modification date: 2022-01-05) |
Primary citation | Harris, J.A.,Faust, B.,Gondin, A.B.,Damgen, M.A.,Suomivuori, C.M.,Veldhuis, N.A.,Cheng, Y.,Dror, R.O.,Thal, D.M.,Manglik, A. Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nat.Chem.Biol., 18:109-115, 2022 Cited by PubMed: 34711980DOI: 10.1038/s41589-021-00890-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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