7RJ2

Co-crystal structure of lenacapavir bound to Q67H/N74D mutant of disulfide stabilized HIV-1 CA hexamer

Summary for 7RJ2

• Entry DOI: 10.2210/pdb7rj2/pdb
• Related: 7RAO 7RAR 7RHM 7RHN
• Descriptor: Capsid protein p24, N-[(1S)-1-(3-{4-chloro-3-[(methylsulfonyl)amino]-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl}-6-[3-methyl-3-(methylsulfonyl)but-1-yn-1-yl]pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl]-2-[(3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl]acetamide, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: inhibitor, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 1
• Total formula weight: 26709.27

Authors

Bester, S.M.,Kvaratskhelia, M. (deposition date: 2021-07-20, release date: 2022-07-27, Last modification date: 2023-10-18)

• Primary citation: Bester, S.M.,Adu-Ampratwum, D.,Annamalai, A.S.,Wei, G.,Briganti, L.,Murphy, B.C.,Haney, R.,Fuchs, J.R.,Kvaratskhelia, M.; Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir.; Mbio, 13:e0180422-e0180422, 2022; PubMed: 36190128; DOI: 10.1128/mbio.01804-22

Experimental method

X-RAY DIFFRACTION (2.32 Å)