7RIL

Crystal structure of hairpin polyamide Py-Im 1 bound to 5' CCTGACCAGG

7RIL の概要

• エントリーDOI: 10.2210/pdb7ril/pdb
• 分子名称: non-template DNA, template DNA, 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, ... (5 entities in total)
• 機能のキーワード: polyamide, small molecule, dna binding molecule, anticancer agent, dna
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7508.47

構造登録者

Oh, J.,Dervan, P.B.,Wang, D. (登録日: 2021-07-20, 公開日: 2022-01-12, 最終更新日: 2024-04-03)

• 主引用文献: Oh, J.,Jia, T.,Xu, J.,Chong, J.,Dervan, P.B.,Wang, D.; RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.; Proc.Natl.Acad.Sci.USA, 119:-, 2022; PubMed: 35022237; DOI: 10.1073/pnas.2114065119

実験手法

X-RAY DIFFRACTION (1.8 Å)