7RFK
CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor Sinefungin
Summary for 7RFK
Entry DOI | 10.2210/pdb7rfk/pdb |
Descriptor | Site-specific DNA-methyltransferase (adenine-specific), DNA Strand 2, DNA Strand 1, ... (7 entities in total) |
Functional Keywords | dna adenine methylation, protein-dna complex, transferase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna |
Biological source | Clostridioides difficile (Peptoclostridium difficile) More |
Total number of polymer chains | 9 |
Total formula weight | 235088.46 |
Authors | Horton, J.R.,Cheng, X.,Zhou, J. (deposition date: 2021-07-14, release date: 2021-09-15, Last modification date: 2023-10-18) |
Primary citation | Zhou, J.,Horton, J.R.,Yu, D.,Ren, R.,Blumenthal, R.M.,Zhang, X.,Cheng, X. Repurposing epigenetic inhibitors to target the Clostridioides difficile- specific DNA adenine methyltransferase and sporulation regulator CamA. Epigenetics, 17:970-981, 2022 Cited by PubMed: 34523387DOI: 10.1080/15592294.2021.1976910 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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