7RFK

CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor Sinefungin

7RFK の概要

• エントリーDOI: 10.2210/pdb7rfk/pdb
• 分子名称: Site-specific DNA-methyltransferase (adenine-specific), DNA Strand 2, DNA Strand 1, ... (7 entities in total)
• 機能のキーワード: dna adenine methylation, protein-dna complex, transferase, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Clostridioides difficile (Peptoclostridium difficile); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 235088.46

構造登録者

Horton, J.R.,Cheng, X.,Zhou, J. (登録日: 2021-07-14, 公開日: 2021-09-15, 最終更新日: 2023-10-18)

• 主引用文献: Zhou, J.,Horton, J.R.,Yu, D.,Ren, R.,Blumenthal, R.M.,Zhang, X.,Cheng, X.; Repurposing epigenetic inhibitors to target the Clostridioides difficile- specific DNA adenine methyltransferase and sporulation regulator CamA.; Epigenetics, 17:970-981, 2022; PubMed: 34523387; DOI: 10.1080/15592294.2021.1976910

実験手法

X-RAY DIFFRACTION (2.05 Å)