7RER

HUMAN IMPDH1 TREATED WITH ATP, IMP, AND NAD+

Summary for 7RER

• Entry DOI: 10.2210/pdb7rer/pdb
• EMDB information: 24437
• Descriptor: Isoform 5 of Inosine-5'-monophosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, INOSINIC ACID (3 entities in total)
• Functional Keywords: metabolism, filament, allostery, adenine, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 451858.26

Authors

Burrell, A.L.,Kollman, J.M. (deposition date: 2021-07-13, release date: 2022-01-12, Last modification date: 2024-06-05)

• Primary citation: Burrell, A.L.,Nie, C.,Said, M.,Simonet, J.C.,Fernandez-Justel, D.,Johnson, M.C.,Quispe, J.,Buey, R.M.,Peterson, J.R.,Kollman, J.M.; IMPDH1 retinal variants control filament architecture to tune allosteric regulation.; Nat.Struct.Mol.Biol., 29:47-58, 2022; PubMed: 35013599; DOI: 10.1038/s41594-021-00706-2

Experimental method

ELECTRON MICROSCOPY (2.6 Å)