7REK

Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-086

7REK の概要

• エントリーDOI: 10.2210/pdb7rek/pdb
• 分子名称: Bromodomain-containing protein 4, N~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1H-indol-6-yl]-N~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bet, jak2, dual brd-kinase inhibitor, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31502.42

構造登録者

Karim, M.R.,Schonbrunn, E. (登録日: 2021-07-13, 公開日: 2021-07-21, 最終更新日: 2023-10-18)

• 主引用文献: Karim, M.R.,Schonbrunn, E.; Crystal structure of the first bromodomain (BD1) of human BRD4 in complex with dual BRD4-JAK2 inhibitor MA9-086; To Be Published,

実験手法

X-RAY DIFFRACTION (1.2 Å)