7RED

Holo Hemophilin from A. baumannii

7RED の概要

• エントリーDOI: 10.2210/pdb7red/pdb
• 分子名称: Hemophilin, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
• 機能のキーワード: heme binding, secreted, metal transport
• 由来する生物種: Acinetobacter baumannii NIPH 201
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25744.57

構造登録者

Bateman, T.J.,Shah, M.,Moraes, T.F. (登録日: 2021-07-12, 公開日: 2021-11-17, 最終更新日: 2024-05-22)

主引用文献

Bateman, T.J.,Shah, M.,Ho, T.P.,Shin, H.E.,Pan, C.,Harris, G.,Fegan, J.E.,Islam, E.A.,Ahn, S.K.,Hooda, Y.,Gray-Owen, S.D.,Chen, W.,Moraes, T.F.
A Slam-dependent hemophore contributes to heme acquisition in the bacterial pathogen Acinetobacter baumannii.
Nat Commun, 12:6270-6270, 2021

PubMed Abstract: Nutrient acquisition systems are often crucial for pathogen growth and survival during infection, and represent attractive therapeutic targets. Here, we study the protein machinery required for heme uptake in the opportunistic pathogen Acinetobacter baumannii. We show that the hemO locus, which includes a gene encoding the heme-degrading enzyme, is required for high-affinity heme acquisition from hemoglobin and serum albumin. The hemO locus includes a gene coding for a heme scavenger (HphA), which is secreted by a Slam protein. Furthermore, heme uptake is dependent on a TonB-dependent receptor (HphR), which is important for survival and/or dissemination into the vasculature in a mouse model of pulmonary infection. Our results indicate that A. baumannii uses a two-component receptor system for the acquisition of heme from host heme reservoirs.

PubMed: 34725337
DOI: 10.1038/s41467-021-26545-9

実験手法

X-RAY DIFFRACTION (1.53 Å)