7RE1

SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC (composite)

Summary for 7RE1

• Entry DOI: 10.2210/pdb7re1/pdb
• EMDB information: 24430
• Descriptor: RNA-directed RNA polymerase, CHAPSO, ALUMINUM FLUORIDE, ... (12 entities in total)
• Functional Keywords: rna-dependent rna polymerase, viral replication-transcription complex, transcription, viral proteins, replication-transcription complex, replication/transcription
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 8
• Total formula weight: 327962.35

Authors

Chen, J.,Malone, B.,Campbell, E.A.,Darst, S.A. (deposition date: 2021-07-12, release date: 2021-12-01, Last modification date: 2024-06-05)

• Primary citation: Chen, J.,Wang, Q.,Malone, B.,Llewellyn, E.,Pechersky, Y.,Maruthi, K.,Eng, E.T.,Perry, J.K.,Campbell, E.A.,Shaw, D.E.,Darst, S.A.; Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex.; Nat.Struct.Mol.Biol., 29:250-260, 2022; PubMed: 35260847; DOI: 10.1038/s41594-022-00734-6

Experimental method

ELECTRON MICROSCOPY (2.91 Å)