7RCY
Crystal structure of C. difficile penicillin-binding protein 2 in complex with ceftobiprole
Summary for 7RCY
Entry DOI | 10.2210/pdb7rcy/pdb |
Descriptor | Penicillin-binding protein, (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ZINC ION, ... (4 entities in total) |
Functional Keywords | peptidoglycan, pbp, pbp2, cell wall, transpeptidase, b-lactam, gram-positive, spore, sporulation, peptide binding protein |
Biological source | Clostridioides difficile (strain R20291) (Peptoclostridium difficile) |
Total number of polymer chains | 1 |
Total formula weight | 104582.46 |
Authors | |
Primary citation | Sacco, M.D.,Wang, S.,Adapa, S.R.,Zhang, X.,Lewandowski, E.M.,Gongora, M.V.,Keramisanou, D.,Atlas, Z.D.,Townsend, J.A.,Gatdula, J.R.,Morgan, R.T.,Hammond, L.R.,Marty, M.T.,Wang, J.,Eswara, P.J.,Gelis, I.,Jiang, R.H.Y.,Sun, X.,Chen, Y. A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile. Nat Commun, 13:4370-4370, 2022 Cited by PubMed: 35902581DOI: 10.1038/s41467-022-32086-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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