7RC9

Crystal structure of human TLR8 ectodomain bound to small molecule antagonist 21

Summary for 7RC9

• Entry DOI: 10.2210/pdb7rc9/pdb
• Descriptor: Toll-like receptor 8, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: toll-like receptor, pattern recognition receptor, pathogen-associated molecular patterns, innate immunity, endosomal receptor, rna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 194116.87

Authors

Critton, D.A. (deposition date: 2021-07-07, release date: 2022-05-04, Last modification date: 2023-10-18)

• Primary citation: Sreekantha, R.K.,Mussari, C.P.,Dodd, D.S.,Pasunoori, L.,Hegde, S.,Posy, S.L.,Critton, D.,Ruepp, S.,Subramanian, M.,Salter-Cid, L.M.,Tagore, D.M.,Sarodaya, S.,Dudhgaonkar, S.,Poss, M.A.,Schieven, G.L.,Carter, P.H.,Macor, J.E.,Dyckman, A.J.; Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8).; Acs Med.Chem.Lett., 13:812-818, 2022; PubMed: 35586440; DOI: 10.1021/acsmedchemlett.2c00049

Experimental method

X-RAY DIFFRACTION (2.76 Å)