7RBX

Crystal structure of isocitrate lyase and phosphorylmutase:isocitrate lyase from Brucella melitensis biovar Abortus 2308 bound to itaconic acid

7RBX の概要

• エントリーDOI: 10.2210/pdb7rbx/pdb
• 分子名称: Isocitrase, 1,2-ETHANEDIOL, 2-methylidenebutanedioic acid, ... (6 entities in total)
• 機能のキーワード: structural genomics, niaid, brucellosis, brucellaceae, covalent inhibitor, itn, substrate analog, icl, glyoxylate cycle, isocitrate, succinate, tca cycle bypass, seattle structural genomics center for infectious disease, ssgcid, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Brucella abortus (strain 2308)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 197739.18

構造登録者

Seattle Structural Genomics Center for Infectious Disease,Edwards, T.E.,Abendroth, J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2021-07-06, 公開日: 2021-10-06, 最終更新日: 2023-10-18)

• 主引用文献: Demars, A.,Vitali, A.,Comein, A.,Carlier, E.,Azouz, A.,Goriely, S.,Smout, J.,Flamand, V.,Van Gysel, M.,Wouters, J.,Abendroth, J.,Edwards, T.E.,Machelart, A.,Hoffmann, E.,Brodin, P.,De Bolle, X.,Muraille, E.; Aconitate decarboxylase 1 participates in the control of pulmonary Brucella infection in mice.; Plos Pathog., 17:e1009887-e1009887, 2021; PubMed: 34525130; DOI: 10.1371/journal.ppat.1009887

実験手法

X-RAY DIFFRACTION (1.8 Å)