7RB1
Isocitrate Lyase-1 from Mycobacterium tuberculosis covalently modified by 5-descarboxy-5-nitro-D-isocitric acid
Summary for 7RB1
Entry DOI | 10.2210/pdb7rb1/pdb |
Descriptor | Isocitrate lyase, dihydroxyacetic acid, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | tuberculosis, glyoxylate shunt, inhibitor, lyase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 4 |
Total formula weight | 190231.25 |
Authors | Krieger, I.V.,Mellott, D.,Meek, T.,Sacchettini, J.C. (deposition date: 2021-07-05, release date: 2021-12-01, Last modification date: 2023-10-18) |
Primary citation | Mellott, D.M.,Torres, D.,Krieger, I.V.,Cameron, S.A.,Moghadamchargari, Z.,Laganowsky, A.,Sacchettini, J.C.,Meek, T.D.,Harris, L.D. Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2 R ,3 S )-2-Hydroxy-3-(nitromethyl)succinic acid. J.Am.Chem.Soc., 143:17666-17676, 2021 Cited by PubMed: 34664502DOI: 10.1021/jacs.1c07970 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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