7R5D
PARP15 catalytic domain in complex with OUL234
Summary for 7R5D
Entry DOI | 10.2210/pdb7r5d/pdb |
Related | 7R3O 7R4A |
Descriptor | Protein mono-ADP-ribosyltransferase PARP15, 6-propan-2-yl-[1,2,4]triazolo[3,4-b][1,3]benzothiazole, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | parp, inhibitor, complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 51174.34 |
Authors | Maksimainen, M.M.,Lehtio, L. (deposition date: 2022-02-10, release date: 2023-01-25, Last modification date: 2024-02-07) |
Primary citation | Murthy, S.,Nizi, M.G.,Maksimainen, M.M.,Massari, S.,Alaviuhkola, J.,Lippok, B.E.,Vagaggini, C.,Sowa, S.T.,Galera-Prat, A.,Ashok, Y.,Venkannagari, H.,Prunskaite-Hyyrylainen, R.,Dreassi, E.,Luscher, B.,Korn, P.,Tabarrini, O.,Lehtio, L. [1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J.Med.Chem., 66:1301-1320, 2023 Cited by PubMed: 36598465DOI: 10.1021/acs.jmedchem.2c01460 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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