7R5B
Crystal structure of BRD4(1) in complex with the inhibitor MPM2
Summary for 7R5B
Entry DOI | 10.2210/pdb7r5b/pdb |
Descriptor | Bromodomain-containing protein 4, 1-(3-aminophenyl)-3-methyl-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrol-4-one, (R,R)-2,3-BUTANEDIOL, ... (6 entities in total) |
Functional Keywords | brd4, brd4(1), bet, mpm2, bromodomain, inhibitor, co-crystal, cocrystal, fragment, protein binding |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 15804.29 |
Authors | Huegle, M. (deposition date: 2022-02-10, release date: 2023-02-08, Last modification date: 2024-02-07) |
Primary citation | Warstat, R.,Pervaiz, M.,Regenass, P.,Amann, M.,Schmidtkunz, K.,Einsle, O.,Jung, M.,Breit, B.,Hugle, M.,Gunther, S. A novel pan-selective bromodomain inhibitor for epigenetic drug design Eur.J.Med.Chem., 249:115139-, 2023 Cited by DOI: 10.1016/j.ejmech.2023.115139PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
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