7R5B

Crystal structure of BRD4(1) in complex with the inhibitor MPM2

Summary for 7R5B

Entry DOI	10.2210/pdb7r5b/pdb
Descriptor	Bromodomain-containing protein 4, 1-(3-aminophenyl)-3-methyl-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrol-4-one, (R,R)-2,3-BUTANEDIOL, ... (6 entities in total)
Functional Keywords	brd4, brd4(1), bet, mpm2, bromodomain, inhibitor, co-crystal, cocrystal, fragment, protein binding
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	15804.29
Authors	Huegle, M. (deposition date: 2022-02-10, release date: 2023-02-08, Last modification date: 2024-02-07)
Primary citation	Warstat, R.,Pervaiz, M.,Regenass, P.,Amann, M.,Schmidtkunz, K.,Einsle, O.,Jung, M.,Breit, B.,Hugle, M.,Gunther, S. A novel pan-selective bromodomain inhibitor for epigenetic drug design Eur.J.Med.Chem., 249:115139-, 2023 Cited by DOI: 10.1016/j.ejmech.2023.115139 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.77 Å)

Structure validation