7R53
Crystal structure of human TLR8 in complex with Compound 15
Summary for 7R53
Entry DOI | 10.2210/pdb7r53/pdb |
Descriptor | Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | toll-like receptor, tlr8, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 192845.35 |
Authors | Faller, M.,Zink, F. (deposition date: 2022-02-10, release date: 2022-03-23, Last modification date: 2024-01-31) |
Primary citation | Betschart, C.,Faller, M.,Zink, F.,Hemmig, R.,Blank, J.,Vangrevelinghe, E.,Bourrel, M.,Glatthar, R.,Behnke, D.,Barker, K.,Heizmann, A.,Angst, D.,Nimsgern, P.,Jacquier, S.,Junt, T.,Zipfel, G.,Ruzzante, G.,Loetscher, P.,Limonta, S.,Hawtin, S.,Andre, C.B.,Boulay, T.,Feifel, R.,Knoepfel, T. Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist. Acs Med.Chem.Lett., 13:658-664, 2022 Cited by PubMed: 35450354DOI: 10.1021/acsmedchemlett.1c00696 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.121 Å) |
Structure validation
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