7R53
Crystal structure of human TLR8 in complex with Compound 15
7R53 の概要
エントリーDOI | 10.2210/pdb7r53/pdb |
分子名称 | Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
機能のキーワード | toll-like receptor, tlr8, immune system |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 192845.35 |
構造登録者 | |
主引用文献 | Betschart, C.,Faller, M.,Zink, F.,Hemmig, R.,Blank, J.,Vangrevelinghe, E.,Bourrel, M.,Glatthar, R.,Behnke, D.,Barker, K.,Heizmann, A.,Angst, D.,Nimsgern, P.,Jacquier, S.,Junt, T.,Zipfel, G.,Ruzzante, G.,Loetscher, P.,Limonta, S.,Hawtin, S.,Andre, C.B.,Boulay, T.,Feifel, R.,Knoepfel, T. Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist. Acs Med.Chem.Lett., 13:658-664, 2022 Cited by PubMed: 35450354DOI: 10.1021/acsmedchemlett.1c00696 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.121 Å) |
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