7R3H
PROSS optimitzed variant of RhlR (75 mutations) in complex with native autoinducer C4-HSL
Summary for 7R3H
Entry DOI | 10.2210/pdb7r3h/pdb |
Descriptor | PROSS optimized variant of RhlR with 75 mutations, N-[(3S)-2-oxotetrahydrofuran-3-yl]butanamide (2 entities in total) |
Functional Keywords | quorum sensing, luxr-type transcriptional regulator, pseudomonas, dna binding protein, gene regulation, mbtl, rhamnolipid, transcription |
Biological source | Pseudomonas aeruginosa PAO1 |
Total number of polymer chains | 4 |
Total formula weight | 111532.68 |
Authors | Henke, S.,Blankenfeldt, W. (deposition date: 2022-02-07, release date: 2022-12-14, Last modification date: 2024-05-01) |
Primary citation | Borgert, S.R.,Henke, S.,Witzgall, F.,Schmelz, S.,Zur Lage, S.,Hotop, S.K.,Stephen, S.,Lubken, D.,Kruger, J.,Gomez, N.O.,van Ham, M.,Jansch, L.,Kalesse, M.,Pich, A.,Bronstrup, M.,Haussler, S.,Blankenfeldt, W. Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa. Nat Commun, 13:7402-7402, 2022 Cited by PubMed: 36456567DOI: 10.1038/s41467-022-35030-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.49 Å) |
Structure validation
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