7R1U

Crystal structure of SARS-CoV-2 nsp10/nsp16 in complex with the WZ16 inhibitor

7R1U の概要

• エントリーDOI: 10.2210/pdb7r1u/pdb
• 分子名称: 2'-O-methyltransferase nsp16, Non-structural protein 10, (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, ... (7 entities in total)
• 機能のキーワード: methyltransferase, nsp10, nsp16, inhibitor, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48121.43

構造登録者

Klima, M.,Boura, E.,Li, F.,Yazdi, A.K.,Vedadi, M. (登録日: 2022-02-03, 公開日: 2022-06-29, 最終更新日: 2024-01-31)

• 主引用文献: Klima, M.,Khalili Yazdi, A.,Li, F.,Chau, I.,Hajian, T.,Bolotokova, A.,Kaniskan, H.U.,Han, Y.,Wang, K.,Li, D.,Luo, M.,Jin, J.,Boura, E.,Vedadi, M.; Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16.; Protein Sci., 31:e4395-e4395, 2022; PubMed: 36040262; DOI: 10.1002/pro.4395

実験手法

X-RAY DIFFRACTION (2.5 Å)