7QZB

BAZ2A bromodomain in complex with acetylpyrrole derivative compound 98

Summary for 7QZB

Entry DOI	10.2210/pdb7qzb/pdb
Related	7QYU 7QZ4
Descriptor	Bromodomain adjacent to zinc finger domain protein 2A, 1,2-ETHANEDIOL, 3-methyl-1-[2-[4-[(4-methyl-1~{H}-pyrazol-3-yl)methyl]piperazin-1-yl]-1,3-thiazol-4-yl]-2,5,6,7-tetrahydroisoindol-4-one, ... (4 entities in total)
Functional Keywords	four helical bundle, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	12836.48
Authors	Dalle Vedove, A.,Cazzanelli, G.,Caflisch, A.,Lolli, G. (deposition date: 2022-01-31, release date: 2022-09-28, Last modification date: 2024-01-31)
Primary citation	Dalle Vedove, A.,Cazzanelli, G.,Batiste, L.,Marchand, J.R.,Spiliotopoulos, D.,Corsi, J.,D'Agostino, V.G.,Caflisch, A.,Lolli, G. Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing. Acs Med.Chem.Lett., 13:1434-1443, 2022 Cited by PubMed: 36105334 DOI: 10.1021/acsmedchemlett.2c00173 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.151 Å)

Structure validation