7QYU

BAZ2A bromodomain in complex with acetylpyrrole derivative compound 88

Summary for 7QYU

Entry DOI	10.2210/pdb7qyu/pdb
Descriptor	Bromodomain adjacent to zinc finger domain protein 2A, 2-[4-[[4-[4-(4-ethanoyl-3-ethyl-5-methyl-1~{H}-pyrrol-2-yl)-1,3-thiazol-2-yl]piperazin-1-yl]methyl]-1,2,3-triazol-1-yl]ethanamide (3 entities in total)
Functional Keywords	four helical bundle, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	12820.44
Authors	Dalle Vedove, A.,Cazzanelli, G.,Caflisch, A.,Lolli, G. (deposition date: 2022-01-29, release date: 2022-09-28, Last modification date: 2024-01-31)
Primary citation	Dalle Vedove, A.,Cazzanelli, G.,Batiste, L.,Marchand, J.R.,Spiliotopoulos, D.,Corsi, J.,D'Agostino, V.G.,Caflisch, A.,Lolli, G. Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing. Acs Med.Chem.Lett., 13:1434-1443, 2022 Cited by PubMed: 36105334 DOI: 10.1021/acsmedchemlett.2c00173 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation