7QRB

Crystal structure of CK1 delta in complex with PK-09-129

Summary for 7QRB

Entry DOI	10.2210/pdb7qrb/pdb
Descriptor	Casein kinase I isoform delta, SULFATE ION, 3-(dimethylamino)-~{N}-[4-[4-(4-fluorophenyl)-5-(1~{H}-pyrrolo[2,3-b]pyridin-4-yl)imidazol-1-yl]cyclohexyl]propane-1-sulfonamide, ... (4 entities in total)
Functional Keywords	kinase, ck1d, inhibitor, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	140854.52
Authors	Chaikuad, A.,Khirsariya, P.,Paruch, K.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2022-01-10, release date: 2023-01-18, Last modification date: 2024-02-07)
Primary citation	Nemec, V.,Khirsariya, P.,Janovska, P.,Moyano, P.M.,Maier, L.,Prochazkova, P.,Kebkova, P.,Gybel', T.,Berger, B.T.,Chaikuad, A.,Reinecke, M.,Kuster, B.,Knapp, S.,Bryja, V.,Paruch, K. Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity. Angew.Chem.Int.Ed.Engl., 62:e202217532-e202217532, 2023 Cited by PubMed: 36625768 DOI: 10.1002/anie.202217532 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation