7QQ4
Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate
Summary for 7QQ4
Entry DOI | 10.2210/pdb7qq4/pdb |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 5,8-dimethyl-2-[2-(1-methyl-4-phenyl-imidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine, ZINC ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, pde, pde10a, schizophrenia, basal ganglia disorders, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 80097.29 |
Authors | Leonard, P.M.,Langgard, M. (deposition date: 2022-01-06, release date: 2023-04-19, Last modification date: 2024-02-07) |
Primary citation | Kehler, J.,Kilburn, J.P.,Langgard, M.,Christoffersen, C.T.,Ritzen, A.,Marigo, M.,Jessing, M.,Bundgaard, C.,Puschl, A.,Feigin, K.,Nielsen, J. Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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