7QKD

Crystal structure of human Cathepsin L in complex with covalently bound MG132

Summary for 7QKD

Entry DOI	10.2210/pdb7qkd/pdb
Related	7QKB 7QKC
Related PRD ID	PRD_001210
Descriptor	Cathepsin L, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywords	cathepsin, cystein protease, drug development, drug target, peptide-like inhibitor, lysosome, protein degradation, sars-cov-2, covid-19, spike protein maturation, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	99359.14
Authors	Reinke, P.Y.A.,Falke, S.,Lieske, J.,Ewert, W.,Loboda, J.,Rahmani Mashhour, A.,Hauser, M.,Karnicar, K.,Usenik, A.,Lindic, N.,Lach, M.,Boehler, H.,Beck, T.,Cox, R.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Guenther, S.,Meents, A. (deposition date: 2021-12-17, release date: 2022-12-28, Last modification date: 2024-05-15)
Primary citation	Falke, S.,Lieske, J.,Herrmann, A.,Loboda, J.,Karnicar, K.,Gunther, S.,Reinke, P.Y.A.,Ewert, W.,Usenik, A.,Lindic, N.,Sekirnik, A.,Dretnik, K.,Tsuge, H.,Turk, V.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A. Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 2024 Cited by PubMed: 38630165 DOI: 10.1021/acs.jmedchem.3c02351 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation