7QH1

Discovery and development of a novel inhaled antivirulence therapy for the treatment of Pseudomonas aeruginosa infections in patients with chronic respiratory disease

7QH1 の概要

• エントリーDOI: 10.2210/pdb7qh1/pdb
• 分子名称: Keratinase KP2, ZINC ION, 2-[2-[[5-[3-[bis(2-hydroxyethyl)-methyl-$l^{4}-azanyl]propoxy]-6-methoxy-1,3-benzothiazol-2-yl]methylcarbamoyl]-5,6-bis(fluoranyl)-1,3-dihydroinden-2-yl]ethanoic acid, ... (5 entities in total)
• 機能のキーワード: pseudomonas aeruginosa, respiratory disease, hydrolase
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 135719.08

構造登録者

Leonard, P.M.,Davies, D.,Pallin, T.D. (登録日: 2021-12-10, 公開日: 2022-12-21, 最終更新日: 2024-02-07)

• 主引用文献: Everett, M.J.,Davies, D.T.,Leiris, S.,Sprynski, N.,Llanos, A.,Castandet, J.M.,Lozano, C.,LaRock, C.N.,LaRock, D.L.,Corsica, G.,Docquier, J.D.,Pallin, T.D.,Cridland, A.,Blench, T.,Zalacain, M.,Lemonnier, M.; Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1 beta in Cellular and Animal Infection Models.; Acs Infect Dis., 9:270-282, 2023; PubMed: 36669138; DOI: 10.1021/acsinfecdis.2c00418

実験手法

X-RAY DIFFRACTION (2.74 Å)