7QGT
Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with AOAA.
Summary for 7QGT
Entry DOI | 10.2210/pdb7qgt/pdb |
Descriptor | Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total) |
Functional Keywords | lyase, methionine cycle, metabolic pathway, serine metabolism |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 126068.22 |
Authors | Hutchin, A.,Kopec, J.,Majtan, T.,Zuhra, K.,Szabo, C. (deposition date: 2021-12-10, release date: 2022-10-19, Last modification date: 2024-01-31) |
Primary citation | Petrosino, M.,Zuhra, K.,Kopec, J.,Hutchin, A.,Szabo, C.,Majtan, T. H 2 S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine. Cell.Mol.Life Sci., 79:438-438, 2022 Cited by PubMed: 35864237DOI: 10.1007/s00018-022-04479-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.691 Å) |
Structure validation
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