7QGT

Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with AOAA.

Summary for 7QGT

• Entry DOI: 10.2210/pdb7qgt/pdb
• Descriptor: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• Functional Keywords: lyase, methionine cycle, metabolic pathway, serine metabolism
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 126068.22

Authors

Hutchin, A.,Kopec, J.,Majtan, T.,Zuhra, K.,Szabo, C. (deposition date: 2021-12-10, release date: 2022-10-19, Last modification date: 2024-01-31)

• Primary citation: Petrosino, M.,Zuhra, K.,Kopec, J.,Hutchin, A.,Szabo, C.,Majtan, T.; H 2 S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine.; Cell.Mol.Life Sci., 79:438-438, 2022; PubMed: 35864237; DOI: 10.1007/s00018-022-04479-9

Experimental method

X-RAY DIFFRACTION (2.691 Å)