7QGT

Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with AOAA.

7QGT の概要

• エントリーDOI: 10.2210/pdb7qgt/pdb
• 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: lyase, methionine cycle, metabolic pathway, serine metabolism
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 126068.22

構造登録者

Hutchin, A.,Kopec, J.,Majtan, T.,Zuhra, K.,Szabo, C. (登録日: 2021-12-10, 公開日: 2022-10-19, 最終更新日: 2024-01-31)

• 主引用文献: Petrosino, M.,Zuhra, K.,Kopec, J.,Hutchin, A.,Szabo, C.,Majtan, T.; H 2 S biogenesis by cystathionine beta-synthase: mechanism of inhibition by aminooxyacetic acid and unexpected role of serine.; Cell.Mol.Life Sci., 79:438-438, 2022; PubMed: 35864237; DOI: 10.1007/s00018-022-04479-9

実験手法

X-RAY DIFFRACTION (2.691 Å)