7QEI

Structure of human MTHFD2L in complex with TH7299

Summary for 7QEI

• Entry DOI: 10.2210/pdb7qei/pdb
• Descriptor: Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: inhibitor, isoform, mthfd2l, 1c-metabolism, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 33331.24

Authors

Gustafsson, R.,Scaletti, E.R.,Stenmark, P. (deposition date: 2021-12-03, release date: 2022-10-12, Last modification date: 2024-01-31)

• Primary citation: Scaletti, E.R.,Gustafsson Westergren, R.,Andersson, Y.,Wiita, E.,Henriksson, M.,Homan, E.J.,Jemth, A.S.,Helleday, T.,Stenmark, P.; The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.; Chemmedchem, 17:e202200274-e202200274, 2022; PubMed: 35712863; DOI: 10.1002/cmdc.202200274

Experimental method

X-RAY DIFFRACTION (2.1 Å)