7QEI
Structure of human MTHFD2L in complex with TH7299
Summary for 7QEI
Entry DOI | 10.2210/pdb7qei/pdb |
Descriptor | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | inhibitor, isoform, mthfd2l, 1c-metabolism, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33331.24 |
Authors | Gustafsson, R.,Scaletti, E.R.,Stenmark, P. (deposition date: 2021-12-03, release date: 2022-10-12, Last modification date: 2024-01-31) |
Primary citation | Scaletti, E.R.,Gustafsson Westergren, R.,Andersson, Y.,Wiita, E.,Henriksson, M.,Homan, E.J.,Jemth, A.S.,Helleday, T.,Stenmark, P. The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors. Chemmedchem, 17:e202200274-e202200274, 2022 Cited by PubMed: 35712863DOI: 10.1002/cmdc.202200274 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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