7QEI

Structure of human MTHFD2L in complex with TH7299

7QEI の概要

• エントリーDOI: 10.2210/pdb7qei/pdb
• 分子名称: Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, (2S)-2-[[4-[[2,4-bis(azanyl)-6-oxidanylidene-1H-pyrimidin-5-yl]carbamoylamino]phenyl]carbonylamino]pentanedioic acid, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: inhibitor, isoform, mthfd2l, 1c-metabolism, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33331.24

構造登録者

Gustafsson, R.,Scaletti, E.R.,Stenmark, P. (登録日: 2021-12-03, 公開日: 2022-10-12, 最終更新日: 2024-01-31)

• 主引用文献: Scaletti, E.R.,Gustafsson Westergren, R.,Andersson, Y.,Wiita, E.,Henriksson, M.,Homan, E.J.,Jemth, A.S.,Helleday, T.,Stenmark, P.; The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.; Chemmedchem, 17:e202200274-e202200274, 2022; PubMed: 35712863; DOI: 10.1002/cmdc.202200274

実験手法

X-RAY DIFFRACTION (2.1 Å)