7QC5

Crystal structure of human wild type transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)-(3-fluoro-5-hydroxyphenyl)methanone compound

7QC5 の概要

• エントリーDOI: 10.2210/pdb7qc5/pdb
• 分子名称: Transthyretin, (3-fluoranyl-5-oxidanyl-phenyl)-[3-nitro-4,5-bis(oxidanyl)phenyl]methanone (3 entities in total)
• 機能のキーワード: thyroxine (t4) binding site, stabilization compound, amyloid fibrils., transport protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28141.13

構造登録者

Varejao, N.,Pinheiro, F.,Pallares, I.,Ventura, S.,Reverter, D. (登録日: 2021-11-22, 公開日: 2022-11-30, 最終更新日: 2024-01-31)

• 主引用文献: Pinheiro, F.,Pallares, I.,Peccati, F.,Sanchez-Morales, A.,Varejao, N.,Bezerra, F.,Ortega-Alarcon, D.,Gonzalez, D.,Osorio, M.,Navarro, S.,Velazquez-Campoy, A.,Almeida, M.R.,Reverter, D.,Busque, F.,Alibes, R.,Sodupe, M.,Ventura, S.; Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.; J.Med.Chem., 65:14673-14691, 2022; PubMed: 36306808; DOI: 10.1021/acs.jmedchem.2c01195

実験手法

X-RAY DIFFRACTION (1.2 Å)