7Q90

Crystal structure of TTBK2 in complex with VNG1.63 (compound 32)

Summary for 7Q90

• Entry DOI: 10.2210/pdb7q90/pdb
• Descriptor: Tau-tubulin kinase 2, PHOSPHATE ION, ~{N}-[4-(4-methoxyphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine, ... (4 entities in total)
• Functional Keywords: kinase, ttbk2, tau tubulin kinase, kinase inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 69790.10

Authors

Chaikuad, A.,Nozal, V.,Martinez, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2021-11-11, release date: 2022-03-09, Last modification date: 2024-01-31)

• Primary citation: Nozal, V.,Martinez-Gonzalez, L.,Gomez-Almeria, M.,Gonzalo-Consuegra, C.,Santana, P.,Chaikuad, A.,Perez-Cuevas, E.,Knapp, S.,Lietha, D.,Ramirez, D.,Petralla, S.,Monti, B.,Gil, C.,Martin-Requero, A.,Palomo, V.,de Lago, E.,Martinez, A.; TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.; J.Med.Chem., 65:1585-1607, 2022; PubMed: 34978799; DOI: 10.1021/acs.jmedchem.1c01942

Experimental method

X-RAY DIFFRACTION (1.6 Å)